Which type of hypoxia is caused by the inability of cells to utilize oxygen, often due to intoxication?

Histotoxic hypoxia is characterized by the inability of cells to use oxygen effectively, primarily due to toxic substances in the body impairing cellular metabolism. An example of this condition occurs with carbon monoxide poisoning or alcohol intoxication, where the presence of these toxins disrupts the cells' ability to utilize the oxygen available to them, despite an adequate supply of oxygen in the bloodstream. This impairment results from the interference with the cellular processes that normally convert oxygen into energy, leading to a situation where oxygen is present but cannot be used effectively by the body's tissues.

Understanding histotoxic hypoxia is crucial, particularly in the context of flying, as it emphasizes the impact of substances that may not only impair cognitive and physical performance but also affect oxygen utilization at the cellular level.